Jean-Sebastien Austin, B.Sc.

Director of Transcriptomics | Research Associate | 2002-present

Mogil, J.S., Miermeister, F., Seifert, F., Strasburg, K., Zimmermann, K., Reinold, H., Austin, J.-S., Bernardini, N., Chesler, E.J., Hofmann, H.A., Hordo, C., Messlinger, K., Nemmani, K.V., Rankin, A.L., Ritchie, J., Siegling, A., Smith, S.B., Sotocinal, S., Vater, A., Lehto, S.G., Klussmann, S., Quirion, R., Michaelis, M., Devor, M., and Reeh, P.W. Variable sensitivity to noxious heat is mediated by differential expression of the CGRP gene. Proc. Natl. Acad. Sci., USA, 102:12938-12943, 2005
Smith, S.B., Marker, C.L., Perry, C., Liao, G., Sotocinal, S.G., Austin, J.-S., Melmed, K., Clark, D.J., Peltz, G., Wickman, K., and Mogil, J.S. Quantitative trait locus and computational mapping identifies Kcnj9 as a candidate gene affecting analgesia from multiple drug classes. Pharmacogenet. Genom., 18:231-242, 2008
Schorscher-Petcu, A. Austin, J.-S., Mogil, J.S., and Quirion, R. Role of central calcitonin gene-related peptide (CGRP) in locomotor, anxiety- and depression-like behaviors in two mouse strains exhibiting a CGRP-dependent difference in thermal pain sensitivity. J. Molec. Neurosci., 39:125-136, 2009
LaCroix-Fralish, M.L., Mo, G., Smith, S.B., Sotocinal, S.G., Ritchie, J., Austin, J.-S., Melmed, K., Schorscher-Petcu, A., Laferriere, A., Lee, T.H., Romanovsky, D., Liao, G., Behlke, M.A., Clark, J.D., Peltz, G., Seguela, P., Dobretsov, M., and Mogil, J.S. The β₃ subunit of the Na+,K+-ATPase mediates variable nociceptive sensitivity in the formalin test. Pain, 144:294-302, 2009
Kest, B., Smith, S.B., Schorscher-Petcu, A., Austin, J.-S., Ritchie, J., Klein, G., Rossi, G.C., Fortin, A., and Mogil, J.S. Gnao1 (Gα_o protein) is a likely genetic contributor to variation in physical dependence on opioids in mice. Neuroscience, 162:1255-1264, 2009
Malfait, A.-M., Ritchie, J., Gil, A.S., Austin, J.-S., Hartke, J., Qin, W., Tortorella, M.D., and Mogil, J.S. ADAMTS-5 deficient mice do not develop mechanical allodynia associated with osteoarthritis following medial meniscal destabilization. Osteoarthr. Cartil, 18:572-580, 2010
Mogil, J.S., Graham, A.C., Ritchie, J., Hughes, S.F., Austin, J.-S., Schorscher-Petcu, A., Langford, D.J., and Bennett, G.J. Hypolocomotion, asymmetrically directed behaviors (licking, lifting, flinching, and shaking) and dynamic weight bearing (gait) changes are not measures of neuropathic pain in mice. Mol. Pain, 6:34, 2010
Lacroix-Fralish, M.L., Austin, J.-S., Zhang, F.Y., Levitin, D.J., and Mogil, J.S. Patterns of pain: meta-analysis of microarray studies of pain. Pain, 152:1888-1898, 2011
Mogil, J.S., Sorge, R.E., LaCroix-Fralish, M.L., Smith, S.B., Fortin, A., Sotocinal, S.G., Ritchie, J.R., Austin, J.-S., Schorscher-Petcu, A., Melmed, K., Czerminski, J., Bittong, R.A., Mokris, J.B., Neubert, J.K., Campbell, C.M., Edwards, R.R., Campbell, J.N., Crawley, J.N., Lariviere, W.R., Wallace, M.R., Sternberg, W.F., Balaban, C.D., Belfer, I., and Fillingim, R.B. Pain sensitivity and vasopressin analgesia are mediated by a gene-sex-environment interaction. Nat. Neurosci., 14:1569-1573, 2011
Sorge, R.E., LaCroix-Fralish, M.L., Tuttle, A.H., Sotocinal, S.G., Austin, J.-S., Ritchie, J., Chanda, M.L., Graham, A.C., Topham, L., Beggs, S., Salter, M.W., and Mogil, J.S. Spinal cord Toll-like receptor 4 mediates inflammatory and neuropathic hypersensitivity in male but not female mice. J. Neurosci., 31:15450-15454, 2011
Sorge, R.E., Trang, T., Dorfman, R., Smith, S.B., Beggs, S., Ritchie, J., Austin, J.-S., Zaykin, D.V., Vander Meulen, H., Costigan, M., Herbert, T.A., Yarkoni-Abitbul, M., Tichauer, D., Livneh, J., Gershon, E., Zheng, M., Tan, K., John, S.L., Slade, G.D., Jordan, J., Woolf, C.J., Peltz, G., Maixner, W., Diatchenko, L., Seltzer, Z., Salter, M.W., and Mogil, J.S. Genetically determined P2X7 receptor pore formation regulates variability in chronic pain sensitivity. Nat. Med., 18:595-599, 2012
Sorge, R.E., LaCroix-Fralish, M.L., Tuttle, A.H., Khoutorsky, A., Sotocinal, S.G.,Austin, J.-S., Melmed, K., Labialle, S., Schmidt, J.V., Wood, J.N., Naumova, A.K., and Mogil, J.S. The yin and yang of pain: variability in formalin test nociception and morphine analgesia produced by the Yin Yang 1 transcription factor gene. Genes, Brain Behav., 12:405-413, 2013
Wieskopf, J.S., Mathur, J., Limapichat, W., Post, M.R., Al-Qazzaz, M., Sorge, R.E., Martin, L.J., Zaykin, D.V., Smith, S.B., Freitas, K., Austin, J.-S., Dai, F., Zhang, J., Marcovitz, J., Tuttle, A.H., Slepian, P.M., Clarke, S., Drenan, R.M., Janes, J., Al Sharari, S., Segall, S.K., Aasvang, E.K., Lai, W., Bittner, R., Richards, C.I., Slade, G.D., Kehlet, H., Walker, J., Maskos, U., Changeux, J.-P., Devor, M., Maixner, W., Diatchenko, L., Belfer, I., Dougherty, D.A., Su, A.I., Lummis, S.C.R., Damaj, M.I., Lester, H.A., Patapoutian, A., and Mogil, J.S. The nicotinic α6 subunit gene determines variability in chronic pain sensitivity via cross-inhibition of P2X2/3 receptors. Science Transl. Med., 7:287ra72, 2015
Sorge, R.E., Mapplebeck, J.C.S., Rosen, S., Beggs, S., Taves, S., Alexander, J.K., Martin, L.J., Austin, J.-S., Sotocinal, S.G., Chen, D., Yang, M., Shi, X.Q., Huang, H., Pillon, N.J., Bilan, P.J., Tu, Y., Klip, A., Ji, R.-R., Zhang, J., Salter, M.W. and Mogil, J.S. Different immune cells mediate mechanical pain hypersensitivity in male and female mice. Nat. Neurosci., 18:1081-1083, 2015
Tuttle, A.H., Tansley, S., Dossett, K., Tohyama, S., Khoutorsky, A., Maldonado-Bouchard, S., Stein, L., Gerstein, L., Crawhall-Duk, H., Pearl, R., Sukosd, M., Leger, P., Hardt, O., Yachnin, D., Austin, J.-S., Chan, C.M., Groves, I., Pooters, T., Martin, L.J., Sonenberg, N., Gkogkas, C.G., and Mogil, J.S. Social propinquity in rodents as measured by tube co?occupancy differs between inbred and outbred genotypes. Proc. Natl. Acad. Sci. USA, 114:5515-5520, 2017
Martin, L.J., Smith, S.B., Khoutorsky, A., Magnussen, C.A., Samoshkin, A., Sorge, R.E., Cho, C., Yosefpour, N., Sivaselvachandran, S., Tohyama, S., Cole, T., Khong, T.M., Mir, E., Gibson, D.G., Wieskopf, J.S., Sotocinal, S.G., Austin, J.-S., Meloto, C.B., Gitt, J.H., Gkogkas, C., Sonenberg, N., Greenspan, J., Fillingim, R.B., Ohrbach, R., Slade, G.D., Knott, C., Dubner, R., Nackley, A.G., Ribeiro-da-Silva, A., Neely, G.G., Maixner, W., Zaykin, D.V., Mogil, J.S., and Diatchenko, L. Epiregulin and EGFR interactions are involved in pain processing. J. Clin. Invest., 127:3353-3363, 2017
Rosen, S.F., Ham, B., Drouin, S., Boachie, N., Chabot-Dore, A.-J., Austin, J.-S., Diatchenko, L., and Mogil, J.S. T cell mediation of pregnancy analgesia affecting chronic pain in mice. J. Neurosci., 37:9819-9827, 2017
Tansley, S.N., Tuttle, A.H., Wu, N., Tohyama, S., Dossett, K., Gerstein, L., Ham, B., Austin, J.-S., Sotocinal, S.G., and Mogil, J.S. Modulation of social behavior and dominance status by chronic pain in mice. Genes Brain Behav., 18:e12514, 2019
Tansley, S.N., Macintyre, L.C., Diamond, L., Sotocinal, S.G., George, N., Meluban, L., Austin, J.-S., Coderre, T.J., Martin, L.J., and Mogil, J.S. Conditioned pain modulation in rodents can feature hyperalgesia or hypoalgesia depending on test stimulus intensity. Pain, 160:784-792, 2019
Muralidharan, A., Sotocinal, S.G., Austin, J.-S., and Mogil, J.S. The influence of aging and duration of injury on the anti-allodynic efficacy of analgesics in laboratory mice. Pain Rep., 5:e824, 2020
Lister, K.C., Maldonado Bouchard, S., Markova, T., Aternali, A., Denecli, P., Donayre Pimentel, S., Majeed, M., Austin, J.-S., Williams, A.C.de C., and Mogil, J.S. Chronic pain produces hypervigilance to predator odor in mice. Curr. Biol., 30:R866-R867, 2020
Muralidharan, A., Sotocinal, S.G., Yousefpour, N., Akkurt, N., Lima, L.V., Tansley, S., Parisien, M., Wang, C., Austin, J.-S., Ham, B., Dutra, G.M.G.S., Rousseau, P., Maldonado-Bouchard, S., Clark, T., Rosen, S.F., Majeed, M.R., Silva, O., Nejade, R., Li, X., Donayre Pimentel, S., Nielsen, C.S., Neely, G.G., Autexier, C., Diatchenko, L., Ribeiro-da-Silva, A., and Mogil, J.S. Long-term male-specific chronic pain via telomere- and p53-mediated spinal cord cellular senescence. J. Clin. Invest., 132:e151817, 2022
Millecamps, M., Sotocinal, S.G., Austin, J.-S., Stone, L.S., and Mogil, J.S. Sex-specific effects of neuropathic pain on long-term pain behavior and mortality in mice. Pain, 164:577‑586, 2023
McCoy, E.S., Park, S.K., Patel, R.P., Ryan, D.F., Mullen, Z.J., Nesbitt, J.J., Lopez, J.E., Taylor-Blake, B., Vanden, K.A., Krantz, J.L., Hu, W., Garris, R.L., Snyder, M.G., Lima, L.V., Sotocinal, S.G., Austin, J.‑S., Kashlan, A.D., Shah, S., Trocinski, A.K., Pudipeddi, S.S., Major, R.M., Bazick, H.O., Klein, M.R., Mogil, J.S., Wu, G., and Zylka, M.J. Development of PainFace software to simplify, standardize, and scale up mouse grimace analysis. Pain, 165:1793-1805, 2024
Yousefpour, N., Tansley, S.N., Locke, S., Sharif, B., Parisien, M., Bourojeni, F.B., Deamond, H., Mathur, V., Rahman-Khan Arana, N., Austin, J.-S., Bourassa, V., Wang, C., Cabana, V.C., Wong, C., Lister, K., Rodrigues, R., St.-Louis, M., Paquet, M.-E., Carroll, M.C., Andrews-Zwilling, Y., Seguela, P., Kania, A., Yednock, T., Mogil, J.S., De Koninck, Y., Diatchenko, L., Khoutorsky, A., and Ribeiro-da-Silva, A. Targeting C1q protects microglia-mediated synaptic removal in neuropathic pain. Nat. Commun., 16:4590, 2025