Dissertation Title: “Novel roles of microglia in neuropathic pain”

Currently in medical school at McGill University (shannon.tansley@mail.mcgill.ca)

  • Tuttle, A.H., Tansley, S., Dossett, K., Tohyama, S., Khoutorsky, A., Maldonado-Bouchard, S., Stein, L., Gerstein, L., Crawhall-Duk, H., Pearl, R., Sukosd, M., Leger, P., Hardt, O., Yachnin, D., Austin, J.-S., Chan, C.M., Groves, I., Pooters, T., Martin, L.J., Sonenberg, N., Gkogkas, C.G., and Mogil, J.S.  Social propinquity in rodents as measured by tube co-occupancy differs between inbred and outbred genotypes. Proc. Natl. Acad. Sci. USA, 114:5515-5520, 2017
  • Tansley, S.N., Wong, C., Uttam, S., Mogil, J.S., and Khoutorsky, A. Translational regulation in the spinal dorsal horn–a key mechanism for development of chronic pain. Neurobiol. Pain, 4:20-26, 2018
  • Uttam, S., Wong, C., Amorim, I.S., Jafarnejad, S.M., Tansley, S.N., Yang, J., Prager-Khoutorsky, M., Mogil, J.S., Gkogkas, C.G., and Khoutorsky, A. Translational profiling of dorsal root ganglia and spinal cord in a mouse model of neuropathic pain. Neurobiol. Pain, 4:35-44, 2018
  • Tansley, S.N., Tuttle, A.H., Wu, N., Tohyama, S., Dossett, K., Gerstein, L., Ham, B., Austin, J.-S., Sotocinal, S.G., and Mogil, J.S. Modulation of social behavior and dominance status by chronic pain in mice. Genes Brain Behav., 18:e12514, 2019
  • Smith, S.B., Parisien, M., Bair, E., Belfer, I., Chabot-Dore, A.-J., Gris, P., Khoury, S. Tansley, S., Torosyan, Y., Zaykin, D.V., Bernhardt, O., de Oliveira Serrano, P., Gracely, R.H., Jain, D., Jarvelin, M.-R., Kaste, L.M., Kerr, K.F., Kocher, T., Lahdesmaki, R., Laniado, N., Laurie, C.C., Laurie, C.A., Mannikko, M., Meloto, C.B., Nackley, A.G., Nelson, S.C., Pesonen, P., Ribeiro-Dasilva, M.C., Rizzatti-Barbosa, C.M., Sanders, A.E., Schwahn, C., Sipila, K., Sofer, T., Teumer, A., Mogil, J.S., Fillingim, R.B., Greenspan, J.D., Ohrbach, R., Slade, G.D., Maixner, W., and Diatchenko, L. Genome-wide association reveals contribution of MRAS to painful temporomandibular disorder in males. Pain, 160:579-591, 2019
  • Parisien, M., Samoshkin, A., Tansley, S.N., Piltonen, M.H., Martin, L.J., El-Hachem, N., Dagostino, C., Allegri, M., Mogil, J.S., Khoutorsky, A., and Diatchenko, L. Genetic pathway analysis reveals a major role for extracellular matrix organization in inflammatory and neuropathic pain. Pain, 160:932-944, 2019
  • Tansley, S.N., Macintyre, L.C., Diamond, L., Sotocinal, S.G., George, N., Meluban, L., Austin, J.-S., Coderre, T.J., Martin, L.J., and Mogil, J.S. Conditioned pain modulation in rodents can feature hyperalgesia or hypoalgesia depending on test stimulus intensity. Pain, 160:784-792, 2019
  • Parisien, M., Samoshkin, A., Tansley, S.N., Piltonen, M.H., Martin, L.J., El-Hachem, N., Dagostino, C., Allegri, M., Mogil, J.S., Khoutorsky, A., and Diatchenko, L. Genetic pathway analysis reveals a major role for extracellular matrix organization in inflammatory and neuropathic pain. Pain, 160:932-944, 2019
  • Tansley, S., Uttam, S., Guzman, A.U., Yaqubi, M., Pacis, A., Parisien, M., Deamond, H., Wong, C., Rabau, O., Brown, N., Haglund, L., Ouellet, J., Santaguida, C., Ribeiro-da-Silva, A., Tahmasebi, S., Prager-Khoutorsky, M., Ragoussis, J., Zhang, J., Salter, M.W., Diatchenko, L., Healy, L.M.*, Mogil, J.S.*, and Khoutorsky, A*. Single-cell RNA sequencing reveals time- and sex-specific responses of mouse spinal cord microglia to peripheral nerve injury and links ApoE to chronic pain. Nat. Commun., 13:843, 2022
  • Muralidharan, A., Sotocinal, S.G., Yousefpour, N., Akkurt, N., Lima, L.V., Tansley, S., Parisien, M., Wang, C., Austin, J.-S., Ham, B., Dutra, G.M.G.S., Rousseau, P., Maldonado-Bouchard, S., Clark, T., Rosen, S.F., Majeed, M.R., Silva, O., Nejade, R., Li, X., Donayre Pimentel, S., Nielsen, C.S., Neely, G.G., Autexier, C., Diatchenko, L., Ribeiro-da-Silva, A., and Mogil, J.S. Long-term male-specific chronic pain via telomere- and p53-mediated spinal cord cellular senescence. J. Clin. Invest., 132:e151817, 2022
  • Rosen, S.F., Lima, L.V., Chen, C., Nejade, R., Zhao, M., Nemoto, W., Toprak, E., Skvortsova, A., Tansley, S.N., Zumbusch, A., Sotocinal, S.G., Pittman, C., and Mogil, J.S. Olfactory exposure to late pregnant and lactating mice causes stress-induced analgesia in male mice. Sci. Adv., 8:eabi9366, 2022
  • Tansley, S., Gu, N., Guzman, A.U., Cai, W., Wong, C., Lister, K., Munoz-Pino, E., Yousefpour, N., Roome, R.B., Heal, J., Wu, N., Castonguay, A., Lean, G., Muir, E.M., Kania, A., Prager-Khoutorsky, M., Zhang, J., Gkogkas, C.G., Fawcett, J.W., Diatchenko, L., Ribeiro-da-Silva, A., De Koninck, Y., Mogil, J.S., and Khoutorsky, A. Microglia-mediated degradation of perineuronal nets promotes pain. Science, 377:80-86, 2022
  • Wong, C., Barkai, O., Wang, F., Perez, C.T., Lev, S., Cai, W., Tansley, S., Yousefpour, N., Hooshmandi, M., Lister, K.C., Latif, M., Cuello, A.C., Prager-Khoutorsky, M., Mogil, J.S., Seguela, P., De Koninck, Y., Ribeiro-da-Silva, A., Binshtok, A.M., and Khoutorsky, A. mTORC2 mediates structural plasticity in distal nociceptive endings that contributes to pain hypersensitivity following inflammation. J. Clin. Invest., 132:e152635, 2022
  • Lister, K.C., Wong, C., Cai, W., Uttam, S., Stecum, P., Rodrigues, R., Hooshmandi, M., Brown, N., Fan, J., Francois-Saint-Cyr, N., Tansley, S., Hovhannisyan, V., Tavares-Ferreira, D., Inturi, N.N., Mazhar, K., Pacis, A., Yang, J., Ribeiro-da-Silva, A., Gkogkas, C.G., Price, T.J., Mogil, J.S.*, and Khoutorsky, A.* 4E-BP1-dependent translation in microglia controls mechanical hypersensitivity. J. Clin. Invest., 135:e180190, 2025.
  • Yousefpour, N., Tansley, S.N., Locke, S., Sharif, B., Parisien, M., Bourojeni, F.B., Deamond, H., Mathur, V., Rahman-Khan Arana, N., Austin, J.-S., Bourassa, V., Wang, C., Cabana, V.C., Wong, C., Lister, K., Rodrigues, R., St.-Louis, M., Paquet, M.-E., Carroll, M.C., Andrews-Zwilling, Y., Seguela, P., Kania, A., Yednock, T., Mogil, J.S., De Koninck, Y., Diatchenko, L., Khoutorsky, A., and Ribeiro-da-Silva, A. Targeting C1q protects microglia-mediated synaptic removal in neuropathic pain. Nat. Commun., 16:4590, 2025.
  • Yousefpour, N., Tansley, S.N., Locke, S., Sharif, B., Parisien, M., Bourojeni, F.B., Deamond, H., Mathur, V., Rahman-Khan Arana, N., Austin, J.-S., Bourassa, V., Wang, C., Cabana, V.C., Wong, C., Lister, K., Rodrigues, R., St.-Louis, M., Paquet, M.-E., Carroll, M.C., Andrews-Zwilling, Y., Seguela, P., Kania, A., Yednock, T., Mogil, J.S., De Koninck, Y., Diatchenko, L., Khoutorsky, A., and Ribeiro-da-Silva, A. Targeting C1q protects microglia-mediated synaptic removal in neuropathic pain. Nat. Commun., 16:4590, 2025.
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  • Cai, W., Haddad, M., Haddad, R., Kesten, I., Hoffman, T., Laan, R., Westfall, S., Defaye, M., Wong, C., Brown, N., Tansley, S., Lister, K.C., Hooshmandi, M., Wang, F., Lorenzo, L.-E., Hovhannisyan, V., Ho-Tieng, D., Kumar, V., Sharif, B., Thurairajah, B., Fan, J., Sahar, T., Clayton, C., Wu, N., Zhang, J., Bar-Yoseph, H., Pitashny, M., Krock, E., Mogil, J.S., Prager-Khoutorsky, M., Seguela, P., Altier, C., King, I.L., De Koninck, Y., Brereton, N.J.B., Gonzalez, E., Shir, Y., Minerbi, A., and Khoutorsky, A. Gut microbiota promotes pain in fibromyalgia. Neuron, in press.