Susana G. Sotocinal, M.Sc.

Director of Phenomics | Research Associate | 2002-present

Mogil, J.S., Miermeister, F., Seifert, F., Strasburg, K., Zimmermann, K., Reinold, H., Austin, J.-S., Bernardini, N., Chesler, E.J., Hofmann, H.A., Hordo, C., Messlinger, K., Nemmani, K.V., Rankin, A.L., Ritchie, J., Siegling, A., Smith, S.B., Sotocinal, S.G., Vater, A., Lehto, S.G., Klussmann, S., Quirion, R., Michaelis, M., Devor, M., and Reeh, P.W. Variable sensitivity to noxious heat is mediated by differential expression of the CGRP gene. Proc. Natl. Acad. Sci., USA, 102:12938-12943, 2005
Langford, D.J., Crager, S.E., Shehzad, Z., Smith, S.B., Sotocinal, S.G., Levenstadt, J.S., Chanda, M.L., Levitin, D.J., and Mogil, J.S. Social modulation of pain as evidence for empathy in mice. Science, 312:1967-1970, 2006
Mogil, J.S., Ritchie, J., Sotocinal, S.G., Smith, S.B., Croteau, S., Levitin, D.J., and Naumova, A.K. Screening for pain phenotypes: analysis of three congenic mouse strains on a battery of nine nociceptive assays. Pain, 126:24-34, 2006
Smith, S.B., Marker, C.L., Perry, C., Liao, G., Sotocinal, S.G., Austin, J.-S., Melmed, K., Clark, D.J., Peltz, G., Wickman, K., and Mogil, J.S. Quantitative trait locus and computational mapping identifies Kcnj9 (GIRK3) as a candidate gene affecting analgesia from multiple drug classes. Pharmacogenet. Genom.,18:231-242, 2008
LaCroix-Fralish, M.L., Mo, G., Smith, S.B., Sotocinal, S.G., Ritchie, J., Austin, J.-S., Melmed, K., Schorscher-Petcu, A., Laferriere, A., Lee, T.H., Romanovsky, D., Liao, G., Behlke, M.A., Clark, J.D., Peltz, G., Seguela, P., Dobretsov, M., and Mogil, J.S. The β₃ subunit of the Na+,K+-ATPase mediates variable nociceptive sensitivity in the formalin test. Pain, 144:294-302, 2009
Langford, D.J., Tuttle, A.H., Brown, K., Deschenes, S., Fischer, D.B., Mutso, A., Root, K.C., Sotocinal, S.G., Stern, M.A., Mogil, J.S., and Sternberg, W.F. Social approach to pain in laboratory mice. Soc. Neurosci., 5:163-170, 2010
Langford, D.J., Bailey, A.L., Chanda, M.L., Clarke, S.E., Drummond, T.E., Echols, S., Glick, S., Ingrao, J., Klassen-Ross, T., LaCroix-Fralish, M.L., Matsumiya, L., Sorge, R.E., Sotocinal, S.G., Tabaka, J.M., Wong, D., van den Maagdenberg, A.M.J.M., Ferrari, M.D., Craig, K.D., and Mogil, J.S. Coding of facial expression of pain in the laboratory mouse. Nat. Meth., 7:447-449, 2010
Schorscher-Petcu, A., Sotocinal, S.G., Ciura, S., Dupre, A., Ritchie, J., Sorge, R.E., Crawley, J.N., Hu, S.-B., Nishimori, K., Young, L.J., Tribollet, E., Quirion, R., and Mogil, J.S. Oxytocin-induced analgesia and scratching are mediated by the vasopressin-1A receptor in the mouse. J. Neurosci., 30:8274-8284, 2010
Fortin, A., Diez, E., Ritchie, J., Sotocinal, S.G., Dube, M.-P., Gagne, M., Paquette, O., Skamene, E., and Mogil, J.S. Positional cloning of a quantitative trait locus contributing to pain sensitivity: possible mediation by Tyrp1 (tyrosinase-related protein 1). Genes Brain Behav., 9:856-867, 2010
Sotocinal, S.G., Sorge, R.E., Zaloum, A., Tuttle, A.H., Martin, L.J., Wieskopf, J.S., Mapplebeck, J.C.S., Wei, P., Zhan, S., Zhang, S., McDougall, J.J., King, O.D., and Mogil, J.S. The Rat Grimace Scale: a partially automated method for quantifying pain in the laboratory rat via facial expressions. Mol. Pain, 7:55, 2011
Mogil, J.S., Sorge, R.E., LaCroix-Fralish, M.L., Smith, S.B., Fortin, A., Sotocinal, S.G., Ritchie, J.R., Austin, J.-S., Schorscher-Petcu, A., Melmed, K., Czerminski, J., Bittong, R.A., Mokris, J.B., Neubert, J.K., Campbell, C.M., Edwards, R.R., Campbell, J.N., Crawley, J.N., Lariviere, W.R., Wallace, M.R., Sternberg, W.F., Balaban, C.D., Belfer, I., and Fillingim, R.B. Pain sensitivity and vasopressin analgesia are mediated by a gene-sex-environment interaction. Nat. Neurosci., 14:1569-1573, 2011
Sorge, R.E., LaCroix-Fralish, M.L., Tuttle, A.H., Sotocinal, S.G., Austin, J.-S., Ritchie, J., Chanda, M.L., Graham, A.C., Topham, L., Beggs, S., Salter, M.W., and Mogil, J.S. Spinal cord Toll-like receptor 4 mediates inflammatory and neuropathic hypersensitivity in male but not female mice. J. Neurosci., 31:15450-15454, 2011
Matsumiya, L.C., Sorge, R.E., Sotocinal, S.G., Tabaka, J.M., Wieskopf, J.S., Zaloum, A., King, O.D., and Mogil, J.S. Using the Mouse Grimace Scale to reevaluate the efficacy of postoperative analgesics in laboratory mice. J. Am. Assoc. Lab. Anim. Sci., 51:42-49, 2012
Shekarabi, M., Moldrich, R., Rasheed, S., Salin-Cantegrel, A., Laganiere, J., Rochesfort, D., Hince, P., Huot, K., Gaudet, R., Kurniawan, N., Sotocinal, S.G., Ritchie, J., Dion, P., Mogil, J.S., Richards, L., and Rouleau, G. Loss of neuronal potassium/chloride cotransporter 3 (KCC3) is responsible for the degenerative phenotype in a conditional mouse model of hereditary motor and sensory neuropathy associated with agenesis of the corpus callosum. J. Neurosci., 32:3865-3876, 2012
Malfait, A.M., Seymour, A.B., Gao, F., Tortorella, M.D., Hellio Le Graverand-Gastineau, M.P., Wood, L.S., Doherty, M., Doherty, S., Zhang, W., Arden, N.K., Vaughn, F.L., Leaverton, P.E., Spector, T.D., Hart, D.J., Maciewicz, R.A., Muir, K.R., Das, R., Sorge, R.E., Sotocinal, S.G., Schorscher-Petcu, A., Valdes, A.M., and Mogil, J.S. A role for PACE4 in osteoarthritis pain: evidence from human genetic association and null mutant phenotype. Ann. Rheum. Dis., 71:1042-1048, 2012
Sorge, R.E., LaCroix-Fralish, M.L., Tuttle, A.H., Khoutorsky, A., Sotocinal, S.G., Austin, J.-S., Melmed, K., Labialle, S., Schmidt, J.V., Wood, J.N., Naumova, A.K., and Mogil, J.S. The yin and yang of pain: variability in formalin test nociception and morphine analgesia produced by the Yin Yang 1 transcription factor gene. Genes, Brain Behav., 12:405-413, 2013
Sorge, R.E., Martin, L.J., Isbester, K.A., Sotocinal, S.G., Rosen, S., Tuttle, A.H., Wieskopf, J.S., Acland, E.L., Dokova, A., Kadoura, B., Leger, P., Mapplebeck, J.C.S., McPhail, M., Delaney, A., Wigerblad, G., Schumann, A.P., Quinn, T., Frasnelli, J., Svensson, C.I., Sternberg, W.F., and Mogil, J.S. Olfactory exposure to males, including human males, stresses rodents. Nat. Meth., 11:629-632, 2014
Szabo, N.E., da Silva, R.V., Sotocinal, S.G., Zeilhofer, H.U., Mogil, J.S., and Kania, A. Hoxb8 intersection defines a role for Lmx1b in excitatory dorsal horn neuron development, spinofugal connectivity and nociception. J. Neurosci., 35:5233-5246, 2015
Sorge, R.E., Mapplebeck, J.C.S., Rosen, S., Beggs, S., Taves, S., Alexander, J.K., Martin, L.J., Austin, J.-S., Sotocinal, S.G., Chen, D., Yang, M., Shi, X.Q., Huang, H., Pillon, N.J., Bilan, P.J., Tu, Y., Klip, A., Ji, R.-R., Zhang, J., Salter, M.W. and Mogil, J.S. Different immune cells mediate mechanical pain hypersensitivity in male and female mice. Nat. Neurosci., 18:1081-1083, 2015
Kahle, K.T., Schmouth, J.F., Lavastre, V., Latremoliere, A., Zhang, J., Andrews, N., Omura, T., Laganiere, J., Rochefort, D., Hince, P., Castonguay, G., Gaudet, R., Mapplebeck, J.C., Sotocinal, S.G., Duan, J., Ward, C., Khanna, A.R., Mogil, J.S., Dion, P.A., Woolf, C.J., Inquimbert, P., and Rouleau, G.A. Inhibition of the kinase WNK1/HSN2 ameliorates neuropathic pain by restoring GABA inhibition. Sci. Signal. 9:ra32, 2016
Parisien, M., Khoury, S., Chabot-Dore, A.-J., Sotocinal, S.G., Slade, G.D., Smith, S.B., Fillingim, R.B., Ohrbach, R., Greenspan, J.D., Maixner, W., Mogil, J.S., Belfer, I., and Diatchenko, L. Effect of human genetic variability on gene transcription in dorsal root ganglia and association with pain phenotypes. Cell Rep., 19:1940-1952, 2017
Martin, L.J., Smith, S.B., Khoutorsky, A., Magnussen, C.A., Samoshkin, A., Sorge, R.E., Cho, C., Yosefpour, N., Sivaselvachandran, S., Tohyama, S., Cole, T., Khong, T.M., Mir, E., Gibson, D.G., Wieskopf, J.S., Sotocinal, S.G., Austin, J.-S., Meloto, C.B., Gitt, J.H., Gkogkas, C., Sonenberg, N., Greenspan, J., Fillingim, R.B., Ohrbach, R., Slade, G.D., Knott, C., Dubner, R., Nackley, A.G., Ribeiro-da-Silva, A., Neely, G.G., Maixner, W., Zaykin, D.V., Mogil, J.S., and Diatchenko, L. Epiregulin and EGFR interactions are involved in pain processing. J. Clin. Invest., 127:3353-3363, 2017
Tuttle, A.H., Molinaro, M.J., Jethwa, J.F., Sotocinal, S.G., Prieto, J.C., Styner, M.A., Mogil, J.S., and Zylka, M.J. A deep neural network to assess spontaneous pain from mouse facial expressions. Mol. Pain 14:1-29, 2018
Tansley, S.N., Tuttle, A.H., Wu, N., Tohyama, S., Dossett, K., Gerstein, L., Ham, B., Austin, J.-S., Sotocinal, S.G., and Mogil, J.S. Modulation of social behavior and dominance status by chronic pain in mice. Genes Brain Behav., 18:e12514, 2019
Tansley, S.N., Macintyre, L.C., Diamond, L., Sotocinal, S.G., George, N., Meluban, L., Austin, J.-S., Coderre, T.J., Martin, L.J., and Mogil, J.S. Conditioned pain modulation in rodents can feature hyperalgesia or hypoalgesia depending on test stimulus intensity. Pain, 160:784-792, 2019
Petitjean, H., Bourojeni, F.B., Tsao, D., Davidova, A., Sotocinal, S.G., Mogil, J.S., Kania, A., and Sharif-Naeini, R. Recruitment of spinoparabrachial neurons by dorsal horn calretinin neurons. Cell Rep., 28:1429-1438, 2019
Muralidharan, A., Sotocinal, S.G., Austin, J.-S., and Mogil, J.S. The influence of aging and duration of injury on the anti-allodynic efficacy of analgesics in laboratory mice. Pain Rep., 5:e824, 2020
Meloto, C.B., Ingelmo, P., Perez, E.V., Pitt, R., Cardenas, V.H.G., Mohamed, N., Sotocinal, S.G., Bourassa, V., Lima, L.V., Ribeiro-da-Silva, A., Mogil, J.S., and Diatchenko, L. Mast cell stabilizer ketotifen fumarate reverses inflammatory but not neuropathic-induced mechanical pain in mice. Pain Rep., 6:e902, 2021
Muralidharan, A., Sotocinal, S.G., Yousefpour, N., Akkurt, N., Lima, L.V., Tansley, S., Parisien, M., Wang, C., Austin, J.-S., Ham, B., Dutra, G.M.G.S., Rousseau, P., Maldonado-Bouchard, S., Clark, T., Rosen, S.F., Majeed, M.R., Silva, O., Nejade, R., Li, X., Donayre Pimentel, S., Nielsen, C.S., Neely, G.G., Autexier, C., Diatchenko, L., Ribeiro-da-Silva, A., and Mogil, J.S. Long-term male-specific chronic pain via telomere- and p53-mediated spinal cord cellular senescence. J. Clin. Invest., 132:e151817, 2022
Rosen, S.F., Lima, L.V., Chen, C., Nejade, R., Zhao, M., Nemoto, W., Toprak, E., Skvortsova, A., Tansley, S.N., Zumbusch, A., Sotocinal, S.G., Pittman, C., and Mogil, J.S. Olfactory exposure to late pregnant and lactating mice causes stress-induced analgesia in male mice. Sci. Adv., 8:eabi9366, 2022
Millecamps, M., Sotocinal, S.G., Austin, J.-S., Stone, L.S., and Mogil, J.S. Sex-specific effects of neuropathic pain on long-term pain behavior and mortality in mice. Pain, 164:577‑586, 2023
Nemoto, W., Kozak, D., Sotocinal, S.G., Tansley, S., Bannister, K., and Mogil, J.S. Monoaminergic mediation of hyperalgesic and analgesic descending control of nociception in mice. Pain, 164:1096-1105, 2023
McCoy, E.S., Park, S.K., Patel, R.P., Ryan, D.F., Mullen, Z.J., Nesbitt, J.J., Lopez, J.E., Taylor-Blake, B., Vanden, K.A., Krantz, J.L., Hu, W., Garris, R.I., Snyder, M.G., Lima, L.V., Sotocinal, S.G., Austin, J.-S., Kashlan, A.D., Shah, S., Trocinski, A.K., Pudipeddi, S.S., Major, R.M., Bazick, H.O., Klein, M.R., Mogil, J.S., Wu, G., and Zylka, M.J. Development of PainFace software to simplify, standardize, and scale-up mouse grimace analysis. Pain, 165:1793-1805, 2024.